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Can gamma knife cause memory loss?

Gamma Knife radiosurgery is a well-established treatment for various brain conditions, including brain metastases, glomus tumors, and glossopharyngeal neuralgia (Samanci, 2024; Kalhoro & Hashim, 2022; Spina et al., 2018). While Gamma Knife radiosurgery is generally considered safe and effective, concerns have been raised about potential side effects such as radiation necrosis, brain edema, and memory deterioration (Weng et al., 2021; Scobioala et al., 2019). Studies have indicated that Gamma Knife radiosurgery can lead to complications like hydrocephalus and normal pressure hydrocephalus, particularly in the post-treatment period (Marshalik et al., 2022; Park et al., 2020). Additionally, the use of Gamma Knife radiosurgery in patients with a history of previous treatments like microsurgical surgery may complicate postoperative recovery (Huang et al., 2021).

Although Gamma Knife radiosurgery is known for its precision and efficacy, there are reports of adverse effects associated with the treatment of large-sized tumors, which may raise concerns about potential memory loss (Park et al., 2019). Furthermore, the implementation of Gamma Knife radiosurgery requires careful planning and consideration of factors such as dose distribution inhomogeneity to ensure optimal outcomes and minimize risks (Dagli et al., 2022). While Gamma Knife radiosurgery has shown promising results in treating various conditions, including refractory obsessive-compulsive disorder and hypothalamic hamartomas, it is essential to weigh the benefits against the potential risks of memory-related side effects (Zaed et al., 2019; Kumar et al., 2019).

In conclusion, while Gamma Knife radiosurgery is a valuable tool in neurosurgical interventions, the possibility of memory loss as a side effect should be considered, especially in cases involving large tumors or in patients with preexisting conditions that may impact postoperative recovery.


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